Single-Gene Test
MTHFR Test
A focused genetic test that reveals how efficiently your body converts folic acid into its active, usable form, methylfolate.
$99 + tax
Why MTHFR?
Is the MTHFR test right for you?
Testing for the MTHFR gene looks at how your body processes folate (vitamin B9) and a protein building block called homocysteine.
Major medical groups do not recommend routine testing, because MTHFR gene variations are incredibly common and rarely cause health problems on their own. However, doctors sometimes use this test in two specific situations:
High homocysteine levels
If a standard blood test shows you have high levels of homocysteine, a doctor might order an MTHFR test to find out if a genetic quirk is causing the buildup, or if it is just caused by diet, kidney issues, or a simple vitamin deficiency.
Planning certain medications (like methotrexate)
The MTHFR gene affects how your body handles methotrexate, a drug used for some cancers and autoimmune diseases like rheumatoid arthritis. The test predicts if you are at a higher risk for severe side effects, so the doctor can adjust your dose or choose a safer medication.
Having an MTHFR variant is not a disease, and it does not mean you will get sick. Doctors simply view it as one small piece of your overall health puzzle.
What's Tested
One gene. Two well-studied variants.
The MTHFR gene
MTHFR (methylenetetrahydrofolate reductase) is an enzyme that converts folate from food and folic acid from supplements into methylfolate, the form your body can actually use for DNA synthesis, repair, and the regulation of homocysteine.
Genetic variants in MTHFR can reduce how efficiently this conversion happens. Two variants are well-characterized in the research and are what this test reports on.
See a sample MTHFR report
Choosing the right test
Is MTHFR the right product for you?
Choose MTHFR if...
Your question is specifically about folate metabolism, and you don't need a broader medication compatibility review.
Get Started with MTHFRChoose Rx Report if...
You want a comprehensive look at how your genetics affect mental-health medications. Rx Report includes a comprehensive gene panel with pharmacist-led interpretation.
Learn About Rx ReportOther Products
Ready to test your MTHFR?
Order your kit, swab at home, and get clear results from a single focused test.