Disability Managers & Rehabilitation Organizations

Early directional results from Manulife’s Personalized Medicine program, which helps members get on the right mental health medication sooner.

8

point average reduction in the PHQ-9 depression score for members who take the test and change their medication

53%

of members who take the test change their mental health medication

82%

of members who change medication report an improvement in symptoms

$2,400

Estimated direct and indirect health-cost savings when a member earning $30 an hour optimizes their medication therapy

6:1

Potential return on investment

Source: Manulife, Personalized Medicine Group Benefits News, 2026.

Since adding drug compatibility testing as a disability management strategy in early 2023, RBC Insurance reports positive results across all lines of business.

150

Eligible referrals across all lines of business in fiscal 2025

54%

of eligible clients agree to a test (81 clients)

84%

of tests completed (68 tests)

2

months saved on average per client

$3,000

Saved per client per month, about $408,000 across 68 clients

Source: RBC Insurance, drug compatibility results, all lines of business, fiscal 2025.