The Science
Clinical Interpretations
How our clinical support tool guides treatment decisions
Neurotransmitter Profiles & Treatment
Low Baseline Serotonin
Chronic stress further reduces levels.
Recommended: SSRIs like citalopram or paroxetine
Normal-High Serotonin, Low Dopamine, Very Low Norepinephrine
SSRIs unhelpful.
Recommended: Bupropion to address motivation and concentration deficits
Low Serotonin and Norepinephrine
Significant depressive symptoms affecting mood and energy.
Recommended: SNRIs like duloxetine or venlafaxine
High Dopamine with Stimulant Use
Risk of psychosis, agitation, or mania.
Recommended: Avoid stimulants; consider SSRIs or SNRIs instead
Serotonin-Dopamine Imbalance
SSRI increases serotonin but may reduce dopamine, causing anhedonia.
Recommended: Add dopaminergic or adrenergic drugs like bupropion or atomoxetine
Low Serotonin with Anxiety/Sleep Issues
SSRI treatment causes increased anxiety and sleep disruption.
Recommended: Add 5-HT2A receptor antagonists (mirtazapine, trazodone) or low-dose antipsychotics
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