What is Second Generation Pharmacogenomics?
Second Generation Pharmacogenomics is the integration of the information obtained from pharmacokinetic and pharmacodynamic genetic testing into algorithms to assess the complex dynamic between these processes and how they affect the effect of drugs.
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Drugs must be properly metabolized for success.
Antidepressants are absorbed by the intestines into the blood stream, then metabolized to their active form to lately be metabolized by the liver.
Metabolization is mainly done by two liver enzymes, CYP2C19 and CYP2D6,
11% of the population have a malfunctioning genetic variant of one these enzymes, while 5% of the population have both.
All available pharmacogenetic tests provide good information when the failure is due to these particular genetic variations, but success here does not guarantee total success.